Short-chain fatty acids (SCFAs), especially acetate, propionate and butyrate, are end products of microbial fermentation of dietary fibers from anaerobic intestinal microbiota in the colon. Branched chain fatty acids are mainly derived from protein fermentation and are present in lower amounts.
SCFAs exert multiple beneficial effects on mammalian metabolism. Besides their function as primary energy sources for luminal colon cells, they are involved in different host-signaling mechanisms.
SCFAs play a significant role in:
And may reduce the risk of developing: