Lipid Mediator Panel



Lipid Mediator Panel

Inflammatory lipid mediators are potent signal molecules derived from the oxidation of phospholipids and ω-6 polyunsaturated fatty acids.

They play significant roles in regulating a multitude of physiological and cellular processes.

Inflammatory lipid mediators are implicated in numerous diseases, including:

  • Inflammatory disorders
  • Cancer
  • Heart diseases

  • Metabolic diseases

  • Neurological diseases


  • This panel measures the eleven key species of inflammatory lipid mediators that are prominent in human plasma

Covered lipid mediators classes are:

  • prostaglandins
  • hydroxyeicosatetraenoic acids (HETE)
  • hydroxyoctadecadienoic acids (HODE)
  • dihydroxy-octadecenoic acids (diHOME)

And their fatty acid precursors:

  • linoleic acid
  • arachidonic acid
  • Advantages

  • Reproducible Results

  • Comprehensive panel covering inflammatory lipid mediator pathways

  • Fully quantitative LC-MS/MS method with minimum of 6 to 8 calibrators per analyte matching stable isotope labeled internal standards for each analyte

  • Low sample volume requirement

  • Method

  • Analysis by LC-MS/MS

  • Sciex Exion UHPLC, coupled to a Sciex 7500+ Triple Quadrupole Mass Spectrometer

Measured Lipid Mediators & Metabolites

12, 13-DiHOME 12-HETE
9, 10-DiHOME 5-HETE
13-HODE Linoleate
9-HODE Arachidonate
15-HETE Prostaglandin E2
Prostaglandin F2α

Sample Requirements

Sample Matrix Sample Amount
Plasma/Serum 200 µL

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