Custom Assay Development & Sample Analysis


Experts in Custom biomarker assay development

Precion specializes in the development, validation, and profiling of LC-MS/MS based small molecule biomarker assays.

With decades of experience, the Precion team has developed metabolite biomarkers covering hundreds of metabolites from all chemical classes.

In-house synthesis capabilities for stable isotope labeled internal standards allow for accurate, dependable, and reproducible results.

1 Assay Development

Precion’s objective in custom assay development is to meet your specific requirements

3 Sample Analysis

Precion is flexible in their ability to utilize many different sample types which can easily be scaled in both large and small amounts

2 Assay Validation

Assay validation assures results are accurate and reproducible



  • Assays are validated following the fit-for-purpose (FFP) approach, with the level of assay characterization determined by the expected content of use of the data

  • Tested parameters include accuracy, precision, specificity, selectivity, recovery, stability, carry-over, and others as required/requested

  • Advantages

  • Precion leverages LC-MS/MS, the “gold standard” methodology, in quantitative analysis of small molecular biomarkers

  • Compared to traditional clinical chemistry assays, LC-MS/MS assays are superior in both sensitivity and selectivity

  • Molecular mass and fragment-mass based detection is universally applicable to the chemically diverse space of small molecules and allows the parallel measurement of many analytes (multiplexing)

  • Precion specializes in multiplexed assays custom-tailored to address the physiochemical diversity of metabolites

  • Robust equipment is used for obtaining sensitive, selective, accurate, and precise measurements

  • Assays are run with a minimum of 6 to 8 calibrators per analyte

  • Precion uses matching stable isotope labeled internal standards for each analyte, which are synthesized in house if not commercially available

  • Calibrator and quality control sample precision (% CV) typically <10%

  • Requires low sample volume

  • Precion Platforms Include
  • Sciex Exion UHPLC

  • Sciex 5500+ Triple Quadrupole Mass Spectrometer

  • Sciex 7500 Triple Quadrupole Mass Spectrometer

Download Our Pathway Chart

Absolute Quantitation of Metabolites Associated with

Microbiome Pathways Interfacing Health and Disease

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Partner with Precion and let our team develop your next superior assay.