Comprehensive Gut Microbiome Specific Metabolite Panel



Gut Microbiome Metabolism

A significant portion of the metabolites in human blood circulation originate from gut microbiome. The direct metabolite exchanges (host-microbe metabolic axes) are central to the interaction between gut microbiome and host.

Many of the gut bacterial-derived metabolites are shown to play key roles in disease and health status such as:

  • Diabetes
  • Cardiovascular diseases
  • Liver diseases

  • Inflammation

  • CNS function

  • Immunity

A large overlap of metabolites is observed between fecal and plasma/serum samples. However, the metabolite patterns in both matrices are different due to their different physiological and metabolic processes.

Precion’s microbiome panel provides a comprehensive coverage of key microbiome metabolic pathways associated with disease and health status shown in the pathway diagram.

Download Pathway Chart Here 

A Focus on Metabolites

Precion’s method, a metabolite based test, reveals what is actually happening.

Whereas a molecular based test used by competitors only shows what might be happening.

Chronic diseases are driven by genetic and non genetic factors that can make them difficult to diagnose on other platforms.

These factors include diet, exercise, medication, genetics, and microbiome.


  • Providing novel insights on how microbiome impacts host’s disease and health status in clinical or experimental studies

  • Evaluating the changes of the host microbiome through dietary, nutraceutical, prebiotics, probiotics, and biopharmaceutical intervention

  • Assessing the homeostasis of gut health

  • Discovering biomarkers associated with gut microbiome actions

  • Advantages

  • Reproducible Results

  • Absolute quantitation of several metabolites associated with gut bacterial metabolism. Absolute quantitation enables direct comparison with existing databases or merging datasets from different experiments

  • Fully quantitative LC-MS/MS method with minimum of 6 to 8 calibrators per metabolite

  • Matching stable isotope labeled internal standards for each of the 70 analytes

  • Calibrator and quality control sample precision (% CV) typically <10%

  • Small amount of sample required

  • Method

  • Analysis by LC-MS/MS

  • Sciex Exion UHPLC coupled to a Sciex 5500+ Triple Quadrupole Mass Spectrometer

Sample Requirements

Sample Matrix Sample Amount
Plasma/Serum 200 µL
Fecal Sample 100 mg
bacterial culture supernatant 200 – 300 µL

Download Tech Sheet for Full List of 85 analytes

Download Our Pathway Chart

Absolute Quantitation of Metabolites Associated with

Microbiome Pathways Interfacing Health and Disease

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