Biological age testing could be key to future precision medicine2.
Aging is associated with the decline of physical and cognitive functions and increased susceptibility to disease. Numerous factors, such as genetics, lifestyle, nutrition, and stress, can significantly impact the aging process. Identifying at-risk individuals with faster aging and implementing intervention could prevent/delay disability and disease and enhance quality of life1.
Because of the strong interest for biological age testing, extensive efforts have been made in the last several decades to discover aging biomarkers, including clinical parameters, epigenetics (DNA methylation), proteomics, metabolomics, and multi-omics3.
The majority of the tests in the marketplace are based on DNA methylation biomarkers. Extensive research in the last decade has shown that altered DNA methylation is associated with aging, thus leading to the concept of “epigenetic clock”4. However, the association between epigenetic clocks and numerous age-related diseases, age-altering lifestyles, and longevity have not been well established5,6. Despite the commercial offerings, a precise and actionable biological age test, either replacing the epigenetic clocks or complementing it, is urgently needed.