Biological Age Test

Overview
Advantages
Method

Overview

Biological Age Test

Biological age testing could be key to future precision medicine2.

Aging is associated with the decline of physical and cognitive functions and increased susceptibility to disease. Numerous factors, such as genetics, lifestyle, nutrition, and stress, can significantly impact the aging process. Identifying at-risk individuals with faster aging and implementing intervention could prevent/delay disability and disease and enhance quality of life1.

Because of the strong interest for biological age testing, extensive efforts have been made in the last several decades to discover aging biomarkers, including clinical parameters, epigenetics (DNA methylation), proteomics, metabolomics, and multi-omics3.

The majority of the tests in the marketplace are based on DNA methylation biomarkers. Extensive research in the last decade has shown that altered DNA methylation is associated with aging, thus leading to the concept of “epigenetic clock”4. However, the association between epigenetic clocks and numerous age-related diseases, age-altering lifestyles, and longevity have not been well established5,6. Despite the commercial offerings, a precise and actionable biological age test, either replacing the epigenetic clocks or complementing it, is urgently needed.

  1. Ferrucci L. et al. Measuring biological aging in humans: A quest. Aging Cell 19:e13080 (2020).
  2. Hood L. Leroy Hood: Reflections on a Legendary Career. Genetic Engineering & Biotechnology News. 41, NO. 1 (2021).
  3. Jylhävä J. et al. Biological Age Predictors. EBioMedicine 21:29-36 (2017).
  4. Horvath S.K., Raj K. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet. 19:371-384 (2018).
  5. Fransquet P.D. et. al. The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis. Clin Epigenetics.11:62 (2019).
  6. Oblak L. et. al. A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration. Ageing Research Reviews 69:101348 (2021).

Applications

  • This panel provides a comprehensive picture of aging status and can better reflect lifestyle change and nutrition/drug interventions.

  • This panel consists of metabolite biomarkers mechanistically associated with key aging processes, such as:

    • Inflammation & oxidative stress
    • Steroid hormone homeostasis
    • Essential metabolic functions
    • Diminished liver and kidney functions
    • Neurological functions
    • Impaired immunity
    • Altered gut microbiome
    • Chronic diseases & mortality

  • Advantages

  • A precise and actionable test is an unmet need today
  • Metabolic biomarkers are effective integrates of genetics, epigenetics, nutrition, lifestyle, microbiome impact, and disease/health end points, and are well suited for assessing the biological aging process.

  • DNA based aging tests are offered at a high price point and lack predicative power and validation

  • Precion’s aging panel has an excellent response to age altering interventions

  • Method

  • Metabolites are well suited for accurate biological age assessment

  • Our mass spectrometry-based assay is reliable, reproductible and cost effective

  • Our panel has an excellent correlation in algorithm training with chronological age (r > 0.95) and an excellent response to age altering interventions

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Absolute Quantitation of Metabolites Associated with

Microbiome Pathways Interfacing Health and Disease

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