Human Milk Oligosaccharide Panel
Human milk oligosaccharides (HMOs) are complex sugars with unique structural diversity which are found in breast milk at significant concentrations.
HMOs are important prebiotics and display many unique health effects for infants. These sugars act by promoting growth of beneficial bacteria in the large intestine, thereby generating short-chain fatty acids which are critical for gut health.
As antiadhesive antimicrobials, HMOs selectively reduce binding of pathogenic bacteria and viruses to the gut epithelium, preventing the emergence of a disease.
Certain HMOs can help establish immunocompetence, both locally and systemically. HMOs may also participate in a gut– brain connection, thereby modulating brain and cognitive development.
Applications
Studies in infant nutrition and therapeutic uses of HMOs
Applications that require measuring low levels of HMOs in biological samples
Pharmacokinetic studies of HMOs, providing insights on dose-response relationships of HMOs in clinical or experimental studies
Key Advantage – Reproducible Results
Fully quantitative LC-MS/MS method with a minimum of 6 to 8 calibrators per analyte
Wide range of sample matrices
Proprietary technology facilitates low level quantitation in biological matrices with excellent accuracy and precision
Matching 13C labelled internal standards for all analytes
HMO isomers are separated (2’-FL/3-FL; LNT/LNnT; 3’-SL/6’-SL)
Calibrator and quality control sample precision (% CV) typically <10%
