Steroid hormones play important roles in many physiological processes. Deep profiling of steroid hormones may provide valuable insights for research and clinical studies. Laboratory tests for numerous steroid hormones, such as testosterone, estradiol, and dehydroepiandrosterone sulfate, are offered from many commercial sources. However, these tests focus on individual or limited combinations of hormonal species and do not provide a comprehensive picture of the entire steroid hormone biosynthesis. Also, the amount of sample required to test an extensive panel, in some situations, make it unpractical due to limited sample material.
Comprehensive panel covering progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens
Low sample volume requirement, 200 µL
Fully quantitative LC-MS/MS method with minimum of 6 to 8 calibrators per analyte
Matching stable labeled internal standards used for each analyte
Calibrator and quality control sample precision (% CV) typically <10%
Please contact us for your steroid hormone service needs.
Gut microbial metabolic activity and the direct metabolite exchanges, referred to as host-microbe metabolic axes, are central to the interaction between gut microbiome and host. Many of the gut bacterial-derived metabolites play key roles in diabetes, cardiovascular diseases, liver diseases, inflammation, and immunity. Assessing the homeostasis of gut bacterial-derived metabolites in plasma or serum samples as well as fecal samples may provide novel insights on how the microbiome impacts host health.
Absolute quantitation of over 60 metabolites associated with gut bacteria metabolism. Absolute quantitation enables direct comparison with existing databases or merging datasets from different experiments.
- Comprehensive coverage of key microbiome pathways available, all associated with human disease and health
Precision – Calibrator and Quality Control sample precision (% CV) typically <10%
Small amount of sample required, typically 100 -200 µl plasma/serum or 100 mg fecal samples
Fast project turnaround time, typically 3-4 weeks for most projects
The Short-Chain Fatty Acid Panel is designed to support studies of the gut microbiome, focusing on this particular class of metabolites.
Absolute quantitation of Acetic acid, Propionic acid, Butyric acid, Isobutyric acid, Valeric acid, 2-Methyl-butyric acid, and Caproic acid (Hexanoic acid)
Precision – Calibrator and Quality Control sample precision (% CV) typically <10%
Small amount of sample required, typically 100 -200 µl plasma/serum or 100 mg fecal samples
Fast turnaround time, typically 3-4 weeks for most projects
Please contact us for your bioanalytical service needs.
Inflammatory lipid mediators are potent signal molecules derived from the oxidation of phospholipids and ω-6 polyunsaturated fatty acids. They play significant roles in regulating a multitude of physiological and cellular processes.
This panel measures the eleven key species of inflammatory lipid mediators that are prominent in human plasma. Covered lipid mediators classes are: prostaglandins, hydroxyeicosatetraenoic acids (HETE), hydroxyoctadecadienoic acids (HODE), dihydroxy-octadecenoic acids (diHOME) and their fatty acid precursors linoleic acid and arachidonic acid.
Fully quantitative LC-MS/MS method with minimum of 6 to 8 calibrators per analyte matching stable labeled internal standards for each analyte
Precision – Calibrator and Quality Control sample precision (% CV) typically <10%
Small amount of sample required, typically 100 -200 µl plasma/serum or 100 mg fecal samples
Fast turnaround time, typically 3-4 weeks for most projects
HMOs are important prebiotics and display many unique health effects for infants. These sugars act by promoting growth of beneficial bacteria in the large intestine, thereby generating short-chain fatty acids which are critical for gut health.
Certain HMOs can help establish immunocompetence, both locally and systemically. HMOs may also participate in a gut– brain connection, thereby modulating brain and cognitive development.
HMO isomers are separated (2’-FL/3-FL; LNT/LNnT; 3’-SL/6’-SL)
Precision – Calibrator and Quality Control sample precision (% CV) typically <10%
Small amount of sample required, typically 100 -200 µl plasma/serum or 100 mg fecal samples
Fast turnaround time, typically 3-4 weeks for most projects
We can rapidly develop custom metabolite assays for a wide variety of sample matrices and analyze study samples with the custom assay. Precion offers comprehensive development, including proprietary standards development for many analytes not commercially available.
Please contact Precion for your custom assay needs.
Precion offers development, sample testing, and commercialization options using state of the art LC-MS/MS mass spectrometry-based quantitative biomarker profiling of endogenous metabolites in biological samples.
Service projects range in application from:
Biomedical Research
Pharmaceutical R&D
Agricultural and Nutritional Sciences
LC-MS/MS-based assays are the “gold standard” in the analysis of small molecular biomarkers due to their superior specificity and capability to multiplex across different analytes in a single assay. All of Precion’s LC-MS/MS-based assays use stable labeled internal standards for each analyte to provide quantitation for reproducible and reliable data. In many cases, Precion synthesizes proprietary standards in-house.
We provide sample analysis services using our own biomarker panel assays and custom build assays developed for a specific client’s needs.
