Bioanalytical Services
Precion offers development, sample testing, and commercialization options using state of the art LC-MS/MS mass spectrometry-based quantitative biomarker profiling of endogenous metabolites in biological samples.
Service projects range in application from:
Biomedical Research
Pharmaceutical R&D
Agricultural and Nutritional Sciences
LC-MS/MS-based assays are the “gold standard” in the analysis of small molecular biomarkers due to their superior specificity and capability to multiplex across different analytes in a single assay. All of Precion’s LC-MS/MS-based assays use stable labeled internal standards for each analyte to provide quantitation for reproducible and reliable data. In many cases, Precion synthesizes proprietary standards in-house.
We provide sample analysis services using our own biomarker panel assays and custom build assays developed for a specific client’s needs.
Comprehensive Microbiome Panel
Gut microbial metabolic activity and the direct metabolite exchanges, referred to as host-microbe metabolic axes, are central to the interaction between gut microbiome and host. Many of the gut bacterial-derived metabolites play key roles in diabetes, cardiovascular diseases, liver diseases, inflammation, and immunity. Assessing the homeostasis of gut bacterial-derived metabolites in plasma or serum samples as well as fecal samples may provide novel insights on how the microbiome impacts host health.
Absolute quantitation of over 60 metabolites associated with gut bacteria metabolism. Absolute quantitation enables direct comparison with existing databases or merging datasets from different experiments.
- Comprehensive coverage of key microbiome pathways available, all associated with human disease and health
Precision – Calibrator and Quality Control sample precision (% CV) typically <10%
Small amount of sample required, typically 100 -200 µl plasma/serum or 100 mg fecal samples
Fast project turnaround time, typically 3-4 weeks for most projects
Short-Chain Fatty Acid Panel
The Short-Chain Fatty Acid Panel is designed to support studies of the gut microbiome, focusing on this particular class of metabolites.
Absolute quantitation of Acetic acid, Propionic acid, Butyric acid, Isobutyric acid, Valeric acid, 2-Methyl-butyric acid, and Caproic acid (Hexanoic acid)
Precision – Calibrator and Quality Control sample precision (% CV) typically <10%
Small amount of sample required, typically 100 -200 µl plasma/serum or 100 mg fecal samples
Fast turnaround time, typically 3-4 weeks for most projects
Please contact us for your bioanalytical service needs.
Custom Biomarker Assay Development and Sample Analysis
We can rapidly develop custom metabolite assays for a wide variety of sample matrices and analyze study samples with the custom assay. Precion offers comprehensive development, including proprietary standards development for many analytes not commercially available.
Please contact Precion for your custom assay needs.
